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AQA GCSE Biology Smart practice A mixed round aimed at your weak spots
Unit 1
Cell biology
Cell division
Chromosomes
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Mitosis and the cell cycle
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Stem cells
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Cell structure
Animal and plant cells
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Cell differentiation
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Cell specialisation
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Culturing microorganisms (biology only)
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Eukaryotes and prokaryotes
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Microscopy
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Transport in cells
Active transport
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Diffusion
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Osmosis
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Unit 2
Organisation
Unit 3
Infection and response
Unit 4
Bioenergetics
Unit 5
Homeostasis and response
Unit 6
Inheritance, variation and evolution
Unit 7
Ecology
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The understanding of genetics (biology only)

Practise 42 exam-style questions on The understanding of genetics (biology only) for AQA GCSE Biology. Write your answer as you would in the exam and get it marked in seconds against the mark scheme, point by point, with an AI tutor on hand if you get stuck.

  • 42 questions
  • 4–5 marks each
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20 questions, marked as you go

Sample questions with model answers

Here are 4 of the questions in this topic, each with a model answer, an explanation of why it earns the marks and the mark scheme an examiner would use.

Question 1

4 marks

Give two examples of evidence (other than DNA) that supports the theory of evolution.

Model answer

Fossil record showing transitional forms; comparative anatomy (homologous structures); biogeography (distribution of species); comparative embryology.

Explanation

Multiple lines of non-molecular evidence support evolution: fossils document change over time and transitional forms, homologous structures indicate common ancestry, geographical distributions match evolutionary history, and embryos of related species show conserved patterns.

Mark scheme
  1. 1 mark

    fossil record / transitional fossils

  2. 1 mark

    homologous structures / comparative anatomy

  3. 1 mark

    biogeography / distribution of species

  4. 1 mark

    comparative embryology / early development similarities

Question 2

4 marks

Mendel used pea plants with clear contrasting characters. Explain why choosing clear, discrete traits made his experimental results easier to interpret.

Model answer

Discrete traits (e.g., round vs wrinkled seeds) show distinct phenotypic categories, producing clear ratios in crosses that reveal patterns of inheritance. Continuous traits would produce overlapping phenotypes making ratios and inheritance patterns harder to detect.

Explanation

Mendel’s careful choice of discontinuous, easily scored traits produced unambiguous data and simple ratios that exposed underlying genetic laws; variable quantitative traits would have obscured such patterns.

Mark scheme
  1. 1 mark

    discrete traits produce distinct categories

  2. 1 mark

    results gave clear ratios that revealed inheritance patterns

  3. 1 mark

    continuous traits would overlap and be harder to analyse

  4. 1 mark

    reduced environmental influence on trait expression

    Accept as reason if stated.

Question 3

5 marks

A population of insects is exposed to a new pesticide. Describe how antibiotic/pesticide resistance can develop in a population and spread.

Model answer

Random mutations produce some resistant individuals. Pesticide kills susceptible ones while resistant survive and reproduce. The resistance allele increases in frequency by natural selection. Gene flow or reproduction spreads the resistance through the population; if resistance has a genetic basis it becomes common.

Explanation

Resistance typically starts from rare genetic mutations; pesticide pressure preferentially removes susceptible individuals so resistant ones survive and breed, increasing the frequency of resistance genes and allowing resistance to spread through the population.

Mark scheme
  1. 1 mark

    random mutation produces resistant individuals

  2. 1 mark

    pesticide kills susceptible individuals so resistant survive (selection)

  3. 1 mark

    survivors reproduce and pass resistance allele to offspring

  4. 1 mark

    resistance allele increases in frequency over generations

  5. 1 mark

    spread via reproduction / migration / gene flow

Question 4

5 marks

Explain how horizontal gene transfer (HGT) complicates reconstruction of evolutionary histories, especially in microbes.

Model answer

HGT moves genes between unrelated organisms, so different genes in the same organism may have different histories. This obscures tree-like relationships and makes genome trees discordant; HGT is common in microbes (plasmids, transduction) so phylogenies based on a single gene may be misleading.

Explanation

Because microbes frequently exchange genes across lineages, phylogenies based on genome sequences can show conflicting signals; HGT therefore makes reconstructing clear ancestry more complex and requires methods that account for gene transfer.

Mark scheme
  1. 1 mark

    HGT transfers genes between unrelated organisms

  2. 1 mark

    organism’s genes can have different evolutionary origins

  3. 1 mark

    tree-like phylogeny is blurred; different genes give different trees

  4. 1 mark

    common in microbes via plasmids, viruses (transduction), transformation

  5. 1 mark

    so using single-gene phylogenies can be misleading for microbes

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