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Pharmacology Introduction: Receptors
This quiz is an example of a summary task that I would set, to recap the main points from the lesson or a given topic. This topic is an introduction to the different types of receptors on membrane surfaces. Answers are given in green, and this is above A level, early undergraduate level material.
Date : 05/11/2020
Author Information
Uploaded by : Akshara
Uploaded on : 05/11/2020
Subject : Biology
Receptor I Quiz A chemical is nothing without it s ____receptors_______? 4 different types of receptors? Ligand gates ion channels, G protein coupled receptors, tyrosine kinase linked, nuclear Main general effect of LGIC? Direct ion channel opening Speed of receptor response for LGIC? Fastest Receptor Agonist Nicotinic Cholinoceptor acetylcholine 5HT3 5HT/seartonin GABAa Gamma Amino Butyric Acid Glycine receptor Glycine What ions does the nicotinic and 5HT3 allow to flow through and what effect does it have on the membrane potential? Na and Ca cause depolarisation What ions does GABAa and Glycine allow to flow through and what effect does it have on the membrane potential? Cl hyperpolarisation LGICR structure consist of (proteins and TMD) 5 proteins= pentamer, each has 4 transmem domains How many regions does the LGCIR have and their names? Extra cellular, transmembrane and intracellular What is running through one of the proteins in a LGICR? 1 polypeptide chain with 1 amino and 1 carboxyl terminal How many ACh is needed to activate a LGICR? 2 What do I mean by activated? Binding and open it- so that the aqueous pore for the ion flow is created. Two types of nicotinic AChR and their corresponding affected location? N1/Nm skeletal N2/Nn- autonomic ganglia in CNS The influx of Na+ due to the binding of ACh to AChR will cause depolarisation (-50mV), What is this type of potential called? Excitatory junction potential (threshold potential) Difference in nAChR subunits between Adult neuromuscular junction and Foetal extrajunctional? Adult subunits are a1, e, a1, B1, delta Foetal- a1, gamma, a1, B1, delta Subunit of N2- Neuronal nAChR? A2, a8, B2, B4 What type of disease is myasthenia Gravis? Autoimmune What is the cause of Myathenia Gravis and the type of nAChR it affects? Degrades a1 subunit of muscle niActh receptor Consequence of Myasthenia Gravis? Muscle weakness, exertion is difficult, fatigue, drooping eyelids, difficulty swallowing What type of nAChR is unaffected? Neuronal bc no a1 In measuring membrane potential, things called MEPPs (Membrane End Plate Potential) exist, WHY? Because of random collisions of presynaptic vesicles on pm so leaking of ach into the cleft and stimulating post synaptic. Do MEPPs exist with people that have Myasthenia Gravis? No What does GABAa generally do when activated? Inhibition v quickly How does GABAa or Glycine cause inhibitory effects? cl- influx- hyperpolarisation
This resource was uploaded by: Akshara