Inherited Disorders (GCSE Biology)

What term describes a permanent change in the DNA sequence that can create a new allele?

Gene therapy aims to treat inherited disorders by delivering a healthy gene to patient cells. What is a common vehicle used to carry the therapeutic gene into human cells?

Which term describes a person who carries a recessive disease allele but does not show the disease symptoms?

A new drug is being developed to treat a genetic disease. Which step must occur before the drug is widely prescribed to patients?

Cystic fibrosis (CF) is caused by a faulty CFTR gene and is inherited as a recessive trait. If two carrier parents (both heterozygous) have a child, what is the probability the child will have CF?

What is a likely consequence of inbreeding (mating of close relatives) in small populations regarding inherited disorders?

Preimplantation genetic diagnosis (PGD) can be used during IVF to test embryos for inherited disorders. What is one main advantage of PGD compared with testing during pregnancy?

Which process explains how populations become better suited to their environment over many generations due to inherited differences?

Which of the following is a likely effect of a mutation in a gene encoding haemoglobin?

Haemophilia is an X-linked recessive disorder. Which child of a carrier mother and an unaffected father is most likely to have haemophilia?

In a population, the frequency of an allele changes over time because individuals with that allele leave more offspring. What is this process called?