Tutor HuntResources Medicine Resources
The Genetics And Biomechanics Of Thoracic Aortic Diseases
Date : 20/08/2023
Literature review: The genetics and biomechanics of thoracic aortic diseasesThoracic aortic aneurysms and aortic
dissections (TAAD) are highly fatal emergencies within cardiothoracic
surgery. With increasing age, thoracic aneurysms become more prevalent
and pose an even greater threat when they develop into aortic
dissections. Both diseases are multifactorial and are influenced by a
multitude of physiological and biomechanical processes. Structural
stability of aorta can be disrupted by genes, such as those for
extracellular matrix and contractile protein, as well as telomere
dysfunction, which leads to senescence of smooth muscle and endothelial
cells. Biomechanical changes such as increased luminal pressure imposed
by hypertension are also very prevalent and lead to structural
instability. Furthermore, ageing is associated with a pro-inflammatory
state that exacerbates degeneration of vessel wall, facilitating the
development of both aortic aneurysms and aortic dissection. This
literature review provides an overview of the aetiology and
pathophysiology of both thoracic aneurysms and aortic dissections. With
an improved understanding, new therapeutic targets may eventually be
identified to facilitate treatment and prevention of these diseases.Keywords: thoracic aorta, biomechanic, aorta, dissection, aneurysm
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7439919/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7439919/
This resource was uploaded by: Ka