Tutor HuntResources Medicine Resources
Estimation Of Regional Bone Metabolism From Whole-body 18f-fluoride Pet Static Images
KEYWORDS mathematical modelling
Date : 06/10/2017
Author Information
Uploaded by : Tanuj
Uploaded on : 06/10/2017
Subject : Medicine
Abstract
PURPOSE:
We evaluate a new quantitative method of acquiring and analysing (18)F positron emission tomography (PET) studies that enables regional bone plasma clearance (K ( i )) to be estimated from static scans acquired at multiple sites in the skeleton following a single injection of tracer.
METHODS:
Dynamic lumbar spine (18)F PET data from two clinical trials were used to simulate a series of static scans acquired 30-60 min after injection. Venous blood samples were taken at 30, 40, 50 and 60 min and K ( i ) evaluated by Patlak analysis and the static scan method. The data were used to evaluate the precision errors of the Patlak and static scan methods expressed as the percentage coefficient of variation (%CV) and compare their response to 6 months of treatment with the bone anabolic agent teriparatide.
RESULTS:
Static scan K ( i ) measurements 30-60 min after injection were highly correlated with the Patlak results (r > 0.99). The %CV for the static scan method was 17.5% 30 min after injection, decreasing to 14.5% at 60 min, compared with 13.0% for Patlak analysis. Response to teriparatide treatment was +25.2% for the static scan method compared with +24.3% for Patlak analysis. The mean ratio (SD) of the static scan and Patlak K ( i ) results was 1.006 (0.015) at 30 min after injection decreasing to 0.965 (0.015) at 60 min.
CONCLUSION:
(18)F-Fluoride bone plasma clearance can be estimated from a static scan and venous blood samples acquired 30-60 min after injection. The method enables K ( i ) to be estimated at multiple skeletal sites with a single injection of tracer.
This resource was uploaded by: Tanuj
Other articles by this author
- [18F]Fluoromisonidazole PET in rectal cancer.
- A method for accurate spatial registration of PET images and histopathology slices
- Semiautomatic region-of-interest validation at the femur in (18)F-fluoride PET/CT.
- Comparison of six quantitative methods for the measurement of bone turnover at the hip and lumbar spine using...
- Validation of image-derived arterial input functions at the femoral artery using 18F-fluoride positron emissio...
- Validation of new image-derived arterial input functions at the aorta using 18F-fluoride positron emission tom...